Pyridostigmine to help constipation in Parkinson’s
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests whether pyridostigmine can improve constipation symptoms in people with Parkinson’s disease. If you have Parkinson’s and functional constipation (with infrequent bowel movements), this study may offer a new medication option and closely track your bowel function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be an adult (18 or older) and able to sign consent
- Be able to swallow and take pills by mouth during the study
- Have Parkinson’s disease that meets specific diagnosis rules used in the UK
- Have functional constipation with three or fewer bowel movements per week
- If you can become pregnant or your partner is pregnant, you must use strict birth control during the study and for 28 days after the last dose
- Do not have certain health issues (including prior bowel surgery or bowel/bladder blockage), and do not have a known allergy to the study drug
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether acupuncture can help relieve constipation in people with Parkinson's disease. If you have both Parkinson's and constipation that is not caused by another medical condition, this study may offer a non-drug treatment option.
This study tests whether a treatment called fecal microbiota transplantation (FMT) can help relieve constipation in people with Parkinson's disease. FMT uses healthy donor stool to improve gut bacteria, which may ease constipation and possibly improve Parkinson's symptoms.
This trial tests whether a special enema system called transanal irrigation can improve constipation in people with Parkinson's disease. It also looks at how the treatment affects gut bacteria and bowel movements.
This study tests whether gentle electrical stimulation of the ear (called TaVNS) can help relieve constipation in people with Parkinson's disease. If you have Parkinson's and struggle with constipation, this treatment aims to improve bowel function without medication.
This study explores how bacteria in the small intestine affect how well the Parkinson's medication L-dopa works. It involves swallowing a special capsule to collect gut samples.
This Phase 2 study tests whether taking probiotics can improve depression and mood symptoms in people with Parkinson’s disease. It’s meant for those with mild to moderate depression and stable Parkinson’s and mood treatments.
Hear when a new Constipation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.