Uterus transplant study to help infertility
Treatments studied
Part of Women’s health & pregnancy clinical trials.
This study tests whether transplanting a uterus can help people who cannot carry a pregnancy become pregnant and give birth. It involves surgery plus medicines to help the body accept the new organ, and then embryo transfer to try to achieve pregnancy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are assigned female at birth, age 18–38 when your egg retrieval happens.
- Your infertility is due to a “uterine factor” (your uterus is not functioning or absent for pregnancy).
- You already have cryopreserved embryos at Johns Hopkins that are labeled “normal” after genetic testing (at least 4–8).
- You must be willing to do embryo transfer after the transplant and try for pregnancy per the study plan.
- You must not smoke (either never smoked or quit more than 6 months ago).
- You need specific blood-type and compatibility results with the donor, and negative pregnancy and infection testing as required.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies transplanting a uterus to allow people with uterine infertility to try pregnancy. It may help some patients who cannot carry a baby because their uterus is missing or nonfunctional, but it requires careful matching and strict health screening for both recipients and donors.
This trial studies whether thawed, previously frozen ovarian tissue can be transplanted to help people with ovarian insufficiency become pregnant. It may help if you already have cryopreserved ovarian tissue stored and your care team feels you’re a good candidate for the procedure.
This trial tests whether receiving a donated uterus can allow pregnancy in women who cannot become pregnant because of an absent or non-working uterus. It also looks at safety and how well the pregnancy and follow-up medicines work after transplant.
This trial looks at whether transplanting a deceased donor uterus can allow pregnancy for people who cannot conceive because their uterus does not work or is absent. You would also need to take anti-rejection medicines and come to frequent follow-up visits after surgery.
This trial studies uterus transplant surgery to help people with “absolute uterine factor infertility” (no working uterus) become pregnant using embryos made by IVF. It checks whether the donated uterus can support pregnancy and safe delivery for participants who meet strict medical and health requirements.
This trial looks at people’s acceptance and experience of receiving a uterus transplant. It may help researchers understand how to support patients considering this option, especially who are younger and have specific health requirements.
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