Clin2
NCT05727176Possibly a fitRecruiting

Futibatinib for advanced bile duct cancer with FGFR2 changes

Advanced CholangiocarcinomaFGFR2 FusionsGene Rearrangement

Part of Cancer clinical trials.

This trial tests futibatinib, a targeted pill, in people with advanced (unresectable) or metastatic bile duct cancer that has an FGFR2 fusion or rearrangement. It may help shrink tumors after standard chemotherapy has stopped working.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
120 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • Have bile duct cancer that cannot be fully removed or has spread (intrahepatic or extrahepatic).
  • Your tumor test must show an FGFR2 gene fusion or rearrangement.
  • You must have already tried at least one gemcitabine + platinum chemotherapy treatment.
  • Your scans must show the cancer got worse after the most recent treatment.
  • You must have measurable tumors on imaging and be able to do normal daily activities (performance status 0 or 1).
  • Your body organs (blood, liver, kidneys) must be strong enough for treatment.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06439485Recruiting· Phase 1/Phase 2
Combination drug therapy for advanced bile duct cancer with FGFR2 change

This trial tests a combination of three drugs (pemigatinib, atezolizumab, and bevacizumab) for people with advanced bile duct cancer that has a specific genetic change called FGFR2 fusion. The goal is to see if this combination can shrink or control the cancer when standard treatments have stopped working.

Houston, Texas
NCT07328919Not yet recruiting· Phase 3
Tinengotinib vs chemotherapy for advanced bile duct cancer with FGFR2 changes

This study tests a new oral medication (tinengotinib) against standard chemotherapy for people with advanced bile duct cancer that has a specific gene change (FGFR2). Doctors want to see if this drug can help shrink or slow the cancer better than current treatments.

Hefei, Anhui
NCT07710885Recruiting· Phase 3
Futibatinib for advanced bile duct cancer

This trial tests a new targeted therapy, futibatinib, for people with advanced or unresectable bile duct cancer who have not had prior treatment for advanced disease. It aims to see if this drug can help shrink or control the cancer.

Brisbane
NCT06722183Recruiting· Phase 2
Futibatinib plus chemo-immunotherapy for advanced colorectal cancer

This trial tests a new combination of drugs (futibatinib plus chemo-immunotherapy) for people with advanced colorectal cancer who have not had prior treatment. It aims to see if this combination can shrink tumors or slow their growth.

Amberg
NCT07862998Not yet recruiting· Phase 2
Pemigatinib for bile duct cancer with FGFR2 changes

This trial tests a pill called pemigatinib for people with bile duct cancer that has spread and has a specific gene change (FGFR2 fusion or rearrangement). It may slow or stop tumor growth. The study is for those whose cancer has progressed after at least one prior treatment.

NCT07745296Not yet recruiting· Phase 3
Targeted treatment after surgery for bile duct and gallbladder cancer

This trial tests whether giving a targeted medicine based on your tumor's genetic makeup, after surgery, can help prevent your bile duct or gallbladder cancer from coming back. It's a new approach that tries to match treatment to your specific cancer biology.

Hear when a new Advanced Cholangiocarcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.