Clin2
NCT05817903Possibly a fitRecruiting

Nivolumab with or without axitinib after prior nivolumab

Metastatic Renal Cell Carcinoma

Treatments studied

Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.

This Phase 2 trial studies whether adding axitinib to nivolumab (or giving nivolumab alone) can better control advanced clear-cell kidney cancer after standard initial treatment with nivolumab plus ipilimumab. It may help by extending response or slowing tumor growth while improving how long treatment works.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
118 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have advanced kidney cancer that is mainly clear-cell type, confirmed by lab tests
  • You already completed nivolumab plus ipilimumab and are not fully in remission and not worsening
  • You have at least one measurable tumor spot on scans
  • Your general health is good (performance status 0 or 1)
  • Your blood tests and organ function (liver/kidney/bone marrow) meet specific minimum levels
  • You have usable tumor tissue on file and can follow study visits and procedures

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05327686Recruiting· Phase 2
Adding focused radiation to immunotherapy for kidney cancer

This Phase 2 trial studies whether adding focused, high-precision radiation to immunotherapy helps people with advanced kidney cancer (that cannot be removed by surgery or has spread). It aims to improve cancer control by combining two treatment approaches.

Birmingham, Alabama
NCT07227415Recruiting· Phase 1/Phase 2
Study of a new drug for advanced kidney cancer

This trial tests a new drug, PF-08634404, alone or with other cancer treatments, for adults with advanced kidney cancer that has not been treated before. It aims to see if the drug can help shrink tumors or stop them from growing.

Phoenix, Arizona
NCT06863311Recruiting· Phase 2
Trial of zanzalintinib with immunotherapy for advanced kidney cancer

This trial tests a new drug combination for people with advanced clear cell kidney cancer that has gotten worse after initial immunotherapy treatment. The goal is to see if adding zanzalintinib to another immunotherapy can help control the cancer.

La Jolla, California
NCT06364631Recruiting· Phase 3
Testing a new approach for advanced kidney cancer

This trial is testing a new treatment for people with advanced kidney cancer that has spread to other parts of the body. It aims to find a better way to manage the disease.

Vienna
NCT05969496Recruiting· Phase 2
Pembrolizumab plus axitinib before kidney surgery for RCC with IVC tumor

This Phase 2 trial tests whether pembrolizumab plus axitinib can shrink kidney cancer before surgery, when there is tumor growth into the inferior vena cava (IVC). It may help make the operation easier and improve chances of long-term control.

Aurora, Colorado
NCT07469683Recruiting· Phase 2
Combination therapy for advanced kidney cancer after first-line treatment

This trial tests a combination of two drugs (SLC-3010 and axitinib) versus axitinib alone for people with advanced clear cell kidney cancer that has progressed after initial treatment. It aims to see if the combination is safer and more effective.

Seoul

Hear when a new Metastatic Renal Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.