First-in-human capsule for advanced solid tumors
Part of Cancer clinical trials.
This Phase 1 study tests a new oral capsule (TY-2699a) in people with advanced or metastatic solid tumors that have limited treatment options. It will look for the safest dose and whether the drug can shrink tumors, especially in certain genetic/biomarker patterns.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old and can sign the study consent form
- You have an advanced or metastatic solid tumor and have tried the standard treatments (or can’t take them)
- Your tumor tests show the needed biomarker pattern (RB-pathway changes, or specific tumor types like TNBC, ER+/HER2- breast cancer, ovarian, small cell lung, prostate, or KRAS-mutant pancreatic cancer)
- You can swallow the capsule whole (no chewing or crushing)
- Your body must be strong enough for treatment: ECOG 0–1, expected to live more than 3 months, and bloodwork/liver/kidney results meet study cutoffs
- You recovered from side effects of prior cancer treatment to mild levels (about grade 1 or less) and you have at least one measurable tumor spot
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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