Improving how CAR T cells are timed for lymphoma outcomes
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This Phase 1 trial tests a method to better time “cell therapy” (CAR T) called Yescarta in people with relapsed or refractory large B-cell lymphoma. The goal is to improve outcomes by optimizing how the body is prepared before CAR T treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older when you sign consent
- You have lymphoma confirmed by biopsy, and it is one of the listed types of large B-cell lymphoma
- Your scans show measurable, active lymphoma lesions (PET-avid and large enough)
- You are a good candidate for standard CAR T for large B-cell lymphoma and you’ve had at least two prior treatment lines, including anti-CD20 treatment and an anthracycline chemotherapy
- You have no active cancer in the brain or spinal fluid (CNS)
- You are well enough to safely receive CAR T (stable health, not needing intensive life-support), and your functional status is 0–1
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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