Study of a virus therapy for recurrent brain cancer
Part of Cancer clinical trials.
This trial tests a virus-based treatment called MVR-C5252 for people whose high-grade glioma or glioblastoma has come back after standard therapy. The virus is injected directly into the tumor to try to kill cancer cells and boost the immune system. The goal is to see if it is safe and if it can shrink the tumor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- Your brain tumor has come back after standard treatment, is at least 1 centimeter in size, and no larger than 3 centimeters
- Your tumor is in a location where a thin tube (catheter) can be safely placed into it, away from critical brain areas
- You have already had radiation therapy and temozolomide chemotherapy and your tumor did not respond
- You have good kidney, liver, and blood cell counts as shown by lab tests
- You are able to have an MRI scan of the brain
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a virus-based treatment for glioblastoma that has come back after standard therapies. The virus is designed to infect and destroy cancer cells while leaving healthy cells alone.
This trial tests a new medicine called C5252 for people whose high-grade glioma (a type of brain tumor) has come back after standard treatment. The medicine is given directly into the brain through a small device placed under the scalp (Ommaya reservoir) after surgery to remove as much of the tumor as possible.
This trial tests a new injection called VRT106 for people whose glioblastoma (a brain tumor) has come back or is growing. It uses a virus that may help the immune system attack the tumor. This study is for those who have not had a similar virus or gene therapy before.
This trial tests a new treatment combining an oncolytic virus with a PD-1 inhibitor for people whose high-grade glioma has come back after standard therapy. The virus is injected directly into the tumor through a device placed in the head, and the drug helps your immune system fight the cancer cells.
This trial tests a two-part treatment: an injected virus (DB107-RRV) plus an oral medication (DB107-FC) for people whose high-grade glioma (a type of brain tumor) has come back. The virus is designed to deliver a gene that makes the tumor sensitive to the oral drug, which then helps kill the cancer cells.
This trial tests a new drug, GC001, injected directly into the tumor in people with high-grade gliomas (WHO grade 3 or 4) that have come back or are growing. It may be an option if standard treatments have stopped working.
Hear when a new Recurrent High Grade Glioma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.