Clin2
NCT07472790Possibly a fitNot yet recruiting

Virus therapy with immunotherapy for recurrent brain tumor

High-grade Glioma

Part of Cancer clinical trials.

This trial tests a new treatment that combines a specially designed virus to attack tumor cells with an immunotherapy drug to help the immune system fight the cancer. It is for people whose high-grade glioma (a type of brain tumor) has come back after standard treatment.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
15 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have a high-grade glioma that has returned or progressed after standard treatment.
  • You have at least one measurable tumor (at least 10 mm in size).
  • You are able to have a device placed in your head for direct tumor treatment.
  • You are generally in good health (able to care for yourself, with a KPS score of 50 or more).
  • You do not have active infections, severe heart problems, or other serious conditions that would make the trial unsafe.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06737146Not yet recruiting· Phase 1
Investigational cell therapy for recurrent high-grade brain tumors

This trial tests an experimental cell therapy (MT027) for people with high-grade brain tumors that have come back or stopped responding to treatment. It targets a protein called B7-H3 found on tumor cells, aiming to attack the cancer.

Wuhan, Hubei
NCT06264388Recruiting· Phase 2
Gene therapy plus oral drug for recurrent brain tumors

This trial tests a two-part treatment: an injected virus (DB107-RRV) plus an oral medication (DB107-FC) for people whose high-grade glioma (a type of brain tumor) has come back. The virus is designed to deliver a gene that makes the tumor sensitive to the oral drug, which then helps kill the cancer cells.

Miami, Florida
NCT07126990Enrolling by invitation· Phase 1/Phase 2
A new virus therapy for untreated high-grade glioma

This trial tests a modified virus that may help treat a type of brain cancer called high-grade glioma. It is for patients who have not yet had any treatment for their tumor.

Beijing, Chaoyang District
NCT06660056Recruiting· Phase 1
GC001 injection for returning or growing high-grade brain tumors

This trial tests a new drug, GC001, injected directly into the tumor in people with high-grade gliomas (WHO grade 3 or 4) that have come back or are growing. It may be an option if standard treatments have stopped working.

Beijing, Beijing Municipality
NCT06763965Enrolling by invitation· Phase 1/Phase 2
BioTTT001 for recurrent high-grade glioma

This trial tests a new drug called BioTTT001 for people whose high-grade brain tumor has come back after standard treatment. The drug is given through a small device placed in the head to deliver it directly to the tumor area.

Beijing, Chaoyang District
NCT05717699Recruiting· Phase 1
Trial of a virus treatment for DIPG in children

This Phase 1 trial tests a lab-made cancer virus (Ad-TD-nsIL12) in children with DIPG whose tumor keeps growing after standard treatment. It mainly focuses on safety and how the treatment works, and it may help shrink or control the tumor by stimulating the immune system.

Beijing, Beijing Municipality

Hear when a new High Grade Glioma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.