Clin2
NCT06134492Possibly a fitRecruiting

Acyclovir for pneumonia patients with HSV-1 on breathing support

Pneumonia, ViralVentilator Associated PneumoniaCommunity-acquired PneumoniaHerpes SimplexHospital-acquired Pneumonia

Treatments studied

Part of Infections, Lungs & breathing, Skin clinical trials.

This trial tests whether acyclovir, an antiviral drug, can help patients with pneumonia who are on breathing support and have herpes simplex virus in their lung fluid. The goal is to see if it improves recovery.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
616 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You need a breathing machine (ventilator) or non-invasive breathing support.
  • A test of your lung fluid has found the herpes simplex virus (HSV-1).
  • You have pneumonia (from any cause, including community, hospital, or ventilator).
  • You are not allergic to acyclovir or similar drugs.
  • You are not pregnant or breastfeeding.
  • You are not currently taking any antiviral medication for herpes (like acyclovir, valacyclovir, or similar).
  • You have not had a solid organ or stem cell transplant.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06217406Not yet recruiting
Early acyclovir for herpes in ventilated patients

This trial tests whether giving the antiviral drug acyclovir early can help people on ventilators who show signs of herpes virus in the throat. The goal is to reduce complications and improve recovery.

NCT06936683Not yet recruiting
Studying herpes simplex virus in severe pneumonia patients

This study looks at how a common virus, herpes simplex virus type 1 (the one that causes cold sores), may reactivate in people with severe pneumonia in the ICU. The goal is to understand this better, which could help with future treatments.

NCT05452928Not yet recruiting· Phase 4
Aciclovir for herpes simplex virus type 2 meningitis

This study tests whether taking an antiviral medicine (aciclovir) by mouth can help people recover from meningitis caused by the herpes simplex virus type 2 (HSV-2). You would receive either the active medicine or a placebo (a pill with no active ingredient) to see if it improves recovery.

NCT05844436AVAILABLE
Expanded access to pritelivir for resistant herpes in immunocompromised people

This trial offers a new antiviral medicine called pritelivir to people with weakened immune systems who have herpes sores that do not get better with standard treatments. Taking pritelivir may help clear these resistant sores when other options have failed.

NCT07341386Recruiting· Phase 4
Preventing herpes outbreaks in autoimmune rheumatic diseases

This trial tests whether a medicine called acyclovir can prevent herpes simplex outbreaks in people who also have an autoimmune rheumatic disease. It may help reduce the number of painful cold sores or genital herpes episodes you experience.

São Paulo, São Paulo
NCT05198570Recruiting
Measuring how acyclovir moves in children with cancer

This study checks how acyclovir behaves in the body when it’s given by mouth or through an IV to children receiving cancer care. It may help doctors better choose doses and monitor the medicine in kids who need prevention or treatment of certain viral infections.

Trieste, TS

Hear when a new Pneumonia, Viral trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.