Clin2
NCT06176885Possibly a fitRecruiting

Immunotherapy plus chemo and targeted therapy for MSS colorectal cancer

Colorectal Cancer

Treatments studied

Part of Cancer, Digestive system clinical trials.

This trial tests adding immunotherapy to standard chemotherapy and targeted therapy for people with metastatic colorectal cancer that is MSS (microsatellite stable) and cannot be removed with surgery. It aims to see if this combination helps shrink tumors and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
36 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You have metastatic colorectal cancer that is MSS (microsatellite stable, meaning it has a stable DNA repair system).
  • Your cancer cannot be removed with surgery at the start of treatment.
  • You are between 18 and 75 years old and weigh at least 40 kg (about 88 lbs).
  • You have not received chemotherapy with irinotecan or a targeted therapy like Fruquintinib before.
  • You do not have an active autoimmune disease or uncontrolled health issues like high blood pressure or bleeding problems.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07874438Not yet recruiting
Combination immunotherapy and chemo for advanced colorectal cancer

This trial tests a new combination of two immunotherapy drugs (iparomlimab and tuvonralimab) with standard chemotherapy and a targeted therapy (cetuximab) as the first treatment for colorectal cancer that has come back or spread. The goal is to see if this combination can shrink tumors and help patients live longer.

Nanjing, Jiangsu
NCT05202314Recruiting
Camrelizumab plus chemo after stent for left bowel cancer

This study tests whether adding camrelizumab (an immune therapy) to chemotherapy—after a stent is placed to open a blocked left-sided colon—improves outcomes. It’s meant for people whose cancer can still be removed with surgery after the blockage is treated.

Beijing, Beijing Municipality
NCT06282445Recruiting· Phase 2
Combination therapy for first-line metastatic colorectal cancer

This trial tests whether adding the immunotherapy drug adebrelimab to standard chemotherapy plus bevacizumab can help people with a specific type of metastatic colorectal cancer that cannot be removed by surgery. It is for patients whose tumors are microsatellite stable (MSS) or have normal mismatch repair (pMMR).

Jinhua, Zhejiang
NCT06841159Recruiting· Phase 2
Personalized radiation plus immunotherapy and chemo for metastatic colorectal cancer

This trial tests a new combination of ultra-precise radiation therapy, immunotherapy, chemotherapy, and targeted therapy for people with metastatic colorectal cancer that has a normal DNA mismatch repair system. The goal is to see if this personalized approach can better control the cancer and improve outcomes.

Shanghai
NCT06791512Recruiting· Phase 3
Chemo Plus Targeted Therapy With or Without Immunotherapy for Colorectal Cancer

This trial compares a standard chemotherapy combination (mFOLFOX6) plus a targeted drug (bevacizumab) with or without an immunotherapy (PD-1 antibody) for locally advanced colorectal cancer. It aims to see if adding the immunotherapy improves outcomes for patients with a specific tumor type (pMMR/MSS).

Guangzhou, Guangdong
NCT07403877Not yet recruiting· Phase 2
Immunotherapy with or without radiation for colorectal cancer

This trial tests giving immunotherapy (a drug that boosts your immune system to fight cancer) with or without radiation before surgery for colorectal cancer that is MSI-High or dMMR. It aims to see if this approach can shrink tumors and improve outcomes.

Shanghai

Hear when a new Colorectal cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.