Chemo Plus Targeted Therapy With or Without Immunotherapy for Colorectal Cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial compares a standard chemotherapy combination (mFOLFOX6) plus a targeted drug (bevacizumab) with or without an immunotherapy (PD-1 antibody) for locally advanced colorectal cancer. It aims to see if adding the immunotherapy improves outcomes for patients with a specific tumor type (pMMR/MSS).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with colon or upper rectal cancer that is a type called adenocarcinoma.
- Your tumor must be 'pMMR' or 'MSS' (a specific genetic profile your doctor can check).
- Your cancer is at a stage where it is growing through the bowel wall but has not spread to other organs (cT4NxM0).
- You have not had any prior chemotherapy, radiation, or surgery for this cancer.
- You do not have serious heart problems, active infections, or autoimmune diseases.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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