High-dose statin combo vs. standard statin for artery disease
Part of Heart & circulation clinical trials.
This trial compares a high-dose combination of rosuvastatin (a statin) and ezetimibe (another cholesterol-lowering drug) versus a standard rosuvastatin-only approach for people with peripheral artery disease (narrowed leg arteries) or widespread artery disease. The goal is to see which strategy better lowers LDL cholesterol and reduces heart and limb risks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 19 and 80 years old.
- You have blocked or narrowed arteries in your legs (like pain when walking) or in at least two other major blood vessel areas (like heart, neck, or aorta).
- You are not currently taking cholesterol medicine, or your LDL cholesterol level is above 70 mg/dL.
- You do not have a severe leg condition that threatens the limb, and you have not had a heart attack, stroke, or leg amputation in the last 6 months.
- You do not have severe liver or kidney problems, and you are not allergic to statins or ezetimibe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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