Nivolumab and relatlimab before surgery for skin cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests if two immunotherapy drugs, nivolumab and relatlimab, given before surgery can help shrink a type of skin cancer called cutaneous squamous cell carcinoma. It's for people whose cancer can be removed with surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a type of skin cancer called cutaneous squamous cell carcinoma that can be removed with surgery.
- You have not had immunotherapy or chemotherapy for this cancer before.
- You do not have an active autoimmune disease or take high-dose steroids.
- You have good kidney, liver, and blood function.
- You are willing to have a new biopsy of your tumor.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a very short course of immunotherapy (nivolumab) before standard surgery for patients with certain types of advanced or hard-to-treat skin cancer (cutaneous squamous cell carcinoma). The goal is to see if this approach can reduce the need for extensive or disfiguring surgery.
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This Phase 2 trial tests pembrolizumab (an immune therapy) given before surgery to see if it can help control high-risk invasive cutaneous squamous cell carcinoma. The goal is to improve outcomes by treating cancer earlier and then following with standard surgery and radiation if needed.
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This trial studies nivolumab, an immune therapy, for skin squamous cell cancer that can’t be cured with surgery or radiation. It aims to see how well the treatment shrinks tumors and helps people live longer or longer without cancer growth.
This trial tests a combination of two drugs—an immunotherapy (PD-1 inhibitor) and a targeted therapy (EGFR inhibitor)—given before surgery for locally advanced squamous cell skin cancer. The goal is to shrink the tumor enough to make surgery safer and more effective.
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