Clinical trials
Cutaneous Squamous Cell Carcinoma clinical trials
Below are recruiting cutaneous squamous cell carcinoma clinical trials, each written for real people, not researchers. We’re tracking 108 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05025813RecruitingPhase 2
Pembrolizumab before surgery or radiation for high-risk skin SCC
This Phase 2 trial tests pembrolizumab (an immune therapy) given before surgery to see if it can help control high-risk invasive cutaneous squamous cell carcinoma. The goal is to improve outcomes by treating cancer earlier and then following with standard surgery and radiation if needed.
Camperdown, New South WalesAges 18 years+ - NCT07869823RecruitingEarly Phase 1
Skin cancer treatment for head and neck
This trial tests a combination of an immunotherapy drug (cemiplimab) and a special kind of radiation for a type of skin cancer called cutaneous squamous cell carcinoma. It is designed for people whose cancer has come back or is hard to treat with standard surgery or radiation.
St Louis, MissouriAges 18 years+ - NCT07791745RecruitingPhase 2/Phase 3
Comparing treatments for advanced head and neck cancer
This trial tests a new combination of treatments for head and neck cancer that has returned or spread and can't be cured with local therapy. It compares a standard chemotherapy with or without an additional drug to see which is more effective and safe.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07746258Recruiting
Checking if skin cancer has spread to nearby lymph nodes
This study uses a test to see if a type of skin cancer called high-risk cutaneous squamous cell carcinoma has spread to lymph nodes. The goal is to learn more about how to detect spread early, which could help guide treatment decisions.
Badalona, BarcelonaAges 18 years+ - NCT05797415Recruiting
Check sentinel lymph node biopsy for several eye skin cancers
This trial studies whether a “sentinel lymph node biopsy” can better detect cancer spread in people with specific cancers of the eye surface and nearby tissues. It may help doctors find the right next treatment by learning whether lymph nodes are involved.
Roma, RomeAges 18–95 - NCT04787042RecruitingPhase 1/Phase 2
Safety and early benefits of ST-067 for advanced solid tumors
This early-stage trial tests ST-067 to see if it is safe and whether it may shrink advanced cancers. It also looks at how the drug moves through the body and affects the immune system.
Scottsdale, ArizonaAges 18 years+ - NCT07606508Recruiting
Tracking skin cancer patients starting systemic treatment
This study follows patients newly diagnosed with cutaneous squamous cell carcinoma (a type of skin cancer) who are beginning systemic treatment (medicine that affects the whole body). Researchers want to understand how these treatments work and track patient outcomes over time.
AmiensAges 18 years+ - NCT07600476RecruitingPhase 1
Safety Study of KUP-101A in Advanced Solid Tumors
This is an early-stage study testing a new drug called KUP-101A in patients with advanced solid cancers (like lung, colon, or breast cancer) that haven't responded to standard treatments. The drug works by activating the immune system to fight cancer.
Munich, BavariaAges 18 years+ - NCT07602842RecruitingPhase 1/Phase 2
Testing IDP-001 for advanced solid tumors
This early-stage trial tests a new drug called IDP-001 in people with advanced cancers that have spread or cannot be surgically removed. The study aims to find the right dose and see how well the drug works against various solid tumors.
Los Angeles, CaliforniaAges 18 years+ - NCT07492914RecruitingPhase 2
Study of pre-surgery drugs for head and neck cancer
This trial tests two medications given before surgery for head and neck cancer. The goal is to see if shrinking the tumor beforehand improves outcomes. If you have operable head and neck squamous cell cancer and are generally healthy, you may be eligible.
Chengdu, SichuanAges 18 years+ - NCT06489197RecruitingPhase 2
AK112 plus chemo for advanced esophageal cancer
This trial tests a new immunotherapy drug (AK112) combined with chemotherapy as a first treatment for advanced esophageal cancer that has spread or cannot be removed. It aims to see if this combination helps shrink tumors and controls the disease longer than chemotherapy alone.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07426484RecruitingPhase 4
Testing cosibelimab for advanced skin cancer in specific patients
This trial tests an immunotherapy drug called cosibelimab for patients with advanced cutaneous squamous cell carcinoma who have either had a kidney transplant or have a blood cancer like lymphoma or myeloma. The goal is to see if it can shrink tumors when surgery or radiation is not an option.
Boston, MassachusettsAges 18 years+ - NCT07419464RecruitingPhase 2
Testing 5-FU for head and neck cancer that has returned
This trial tests the drug 5-fluorouracil (5-FU) in people with head and neck cancer that has come back or spread. It aims to see if 5-FU can help when other treatments have stopped working.
St Louis, MissouriAges 18 years+ - NCT07402616Recruiting
Studying skin cancer tumors after surgery
This trial looks at skin cancer tumors removed during surgery to better understand how they grow. It may help you if you are an adult with a common type of skin cancer called squamous cell carcinoma that is not in a sensitive area and is not too large.
CopenhagenAges 18 years+ - NCT07347392Enrolling by invitation
Radiation therapy for head and neck skin cancer study
This study looks at the role of radiation therapy in treating non-melanoma skin cancers (like basal cell carcinoma or squamous cell carcinoma) on the head and neck. It may help doctors better understand how well this treatment works and who benefits most.
Aarhus NAges 18 years+ - NCT07337161Recruiting
Radiation for skin cancer that spread to neck lymph nodes
This trial tests a focused radiation treatment after surgery for people with a common skin cancer (squamous cell carcinoma) that has spread to the lymph nodes in the neck or near the ear. The goal is to see if this approach can prevent the cancer from coming back.
London, OntarioAges 18 years+ - NCT05741073Recruiting
Study of European registry data for advanced skin cancers
This study uses information from a European registry to learn how real-world treatments work for advanced non-melanoma skin cancers. It may help doctors improve care in the future, especially for people who have had surgery and radiation or who cannot have curative treatments.
BrusselsAges 18 years+ - NCT07290010RecruitingPhase 2
Iparomlimab plus chemotherapy for advanced esophageal cancer
This trial tests a combination of two immunotherapy drugs (Iparomlimab and Tuvonralimab) with chemotherapy as a first treatment for advanced esophageal squamous cell carcinoma. It aims to see if this combination is safe and effective for people whose cancer cannot be removed by surgery or has spread.
Shijiazhuang, HebeiAges 18 years+ - NCT07288073RecruitingPhase 2
TIL Therapy for Advanced Skin Cancer Patients
This study tests a personalized cell therapy called TIL (tumor-infiltrating lymphocytes) for people with advanced skin cancers that have not responded to immunotherapy. Doctors take your tumor cells, grow immune cells from them, and then infuse them back to fight the cancer.
Boston, MassachusettsAges 18 years+ - NCT06879964Recruiting
Radiation after surgery for high-grade skin cancer
This study looks at whether radiation therapy after surgery helps people with a high-grade type of skin cancer called squamous cell carcinoma. It may help doctors understand who benefits most from this additional treatment.
Pavia, PaviaAges 18 years+ - NCT07286318RecruitingEarly Phase 1
Niacinamide cream for skin cancer prevention in transplant patients
This trial tests if a daily cream with 5% niacinamide (a form of vitamin B3) can help prevent skin cancer in people who have had an organ transplant. You will apply the cream to your skin and also use sunscreen every day.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07223424RecruitingPhase 2
Patient preference study: shot vs infusion for immunotherapy
This study compares two ways to take immunotherapy drugs (nivolumab or pembrolizumab): as a shot under the skin (subcutaneous) versus an infusion into a vein (intravenous). It looks at which method patients prefer and is for people with certain advanced cancers where these drugs are already approved.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07228442RecruitingPhase 2
Study of L19IL2 and L19TNF for advanced skin cancer
This trial tests a combination of two drugs, L19IL2 and L19TNF, which are injected directly into skin tumors. It is for patients with advanced cutaneous squamous cell carcinoma that has not responded to or cannot tolerate immune checkpoint inhibitor therapy.
Orange, CaliforniaAges 18 years+ - NCT07217171RecruitingPhase 1
Study of EVOLVE104 for advanced bladder and squamous cell cancers
This trial tests an experimental drug called EVOLVE104 for people with advanced bladder cancer or certain types of squamous cell cancers. It aims to see if the drug is safe and if it can help shrink tumors.
Duarte, CaliforniaAges 18 years+
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Cutaneous Squamous Cell Carcinoma trials by city
Studies with a site in or near these metro areas.
Cutaneous Squamous Cell Carcinoma trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cutaneous squamous cell carcinoma?
- Yes. Clin2 currently lists 108 recruiting cutaneous squamous cell carcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cutaneous squamous cell carcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cutaneous squamous cell carcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.