Clin2
NCT06461910Possibly a fitRecruiting

Immunotherapy, thymalfasin, and chemo before surgery for stomach cancer

Gastric CancerEsophagogastric Junction Adenocarcinoma

Treatments studied

Part of Cancer, Digestive system clinical trials.

This trial is testing a combination of three medicines—an immunotherapy (anti-PD-1), an immune booster (thymalfasin), and a chemotherapy regimen (SOX)—given before surgery to shrink stage III stomach or gastroesophageal junction cancer and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
30 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are between 18 and 75 years old.
  • You have stage III stomach or gastroesophageal junction cancer (HER2-negative) that can be removed with surgery.
  • You have not had any prior chemotherapy, radiation, or immunotherapy for this cancer.
  • You are in good overall health with normal organ function (kidney, liver, bone marrow) and can tolerate surgery.
  • You are willing to use contraception (if applicable) and avoid pregnancy for several months after treatment.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07277439Recruiting· Phase 2
Immunotherapy and chemoradiation before surgery for stomach cancer

This study tests combining an immunotherapy drug (PD-1 inhibitor) and a medication to boost your immune system (thymalfasin) with standard chemotherapy and radiation before surgery for stage III cancer where the stomach meets the esophagus. The goal is to see if this approach can shrink the tumor and improve outcomes.

Nanjing, Jiangsu
NCT06155383Recruiting· Phase 2
Surgery and immunotherapy combo for stomach cancer

This trial tests a combination of three drugs (Disitamab Vedotin, Toripalimab, and XELOX) given before and after surgery for gastric or gastroesophageal junction cancer. The goal is to see if this treatment helps shrink the tumor and prevent it from coming back.

Beijing, Beijing Municipality
NCT05914610Not yet recruiting· Phase 3
Combination therapy before surgery for advanced stomach cancer

This trial tests a combination of three drugs (envollizumab, fruquintinib, and chemotherapy) given before surgery, to see if it can shrink stomach cancer enough to make it removable. It compares this combination to chemotherapy alone.

NCT06054906Recruiting· Phase 2
Immunotherapy plus chemo before surgery for stomach cancer

This trial tests a combination of an immunotherapy drug (sintilimab) and a low-dose weekly chemotherapy regimen before surgery for locally advanced stomach cancer that can be removed. The goal is to see if this approach helps shrink the tumor and improve outcomes.

Shanghai
NCT06310473Not yet recruiting· Phase 2
Immunotherapy plus chemotherapy before surgery for stomach cancer

This trial tests a new combination of an immunotherapy drug (cadonilimab) with chemotherapy before surgery for stomach cancer. The goal is to see if this approach shrinks tumors more effectively and improves outcomes.

Guangzhou, Guangdong
NCT07859410Not yet recruiting
Immunotherapy plus chemoradiation before surgery for stomach cancer

This trial tests whether adding an immunotherapy drug called sintilimab to chemotherapy and radiation before surgery can help shrink tumors and improve outcomes for people with gastroesophageal junction cancer. It is designed for patients who have not had previous treatment for this cancer.

Hefei, Anhui

Hear when a new Gastric Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.