Novel TMS for hard-to-treat depression
Part of Mental health clinical trials.
This trial tests a new type of transcranial magnetic stimulation (TMS) for people with severe depression that hasn't improved with multiple medications or therapy. It uses a different frequency pattern to target brain circuits.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 21 and 75 years old.
- You have severe major depression (confirmed by a doctor or a score of 17 or higher on a depression scale).
- You have tried at least 2 different antidepressants from different classes without success.
- You have tried at least 2 additional treatments (like therapy or other medications, but not benzodiazepines) without success.
- You have tried an effective type of talk therapy for a good length of time.
- You are willing to attend all treatment and study visits.
- You do not have certain health conditions (like epilepsy, dementia, a recent stroke, or metal implants near your head).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study combines mindfulness practice with transcranial magnetic stimulation (TMS)—a non-invasive brain stimulation technique—to help people with depression that hasn't improved with antidepressant medications. The goal is to see if adding mindfulness to TMS improves how well the treatment works.
This trial tests a new way to use magnetic stimulation (TMS) to treat depression by targeting a specific brain circuit. It aims to be more precise and may help people whose current treatment hasn't worked well enough.
This trial tests an accelerated form of TMS (a treatment that uses magnetic pulses to stimulate the brain) for people with severe depression who have recently been in a psychiatric hospital. It aims to see if a faster schedule of TMS can help improve symptoms quickly.
This trial tests whether combining fMRI brain scans with TMS (a non-invasive brain stimulation) can help treat depression more effectively. It is for adults with major depressive disorder who can safely undergo MRI.
This study tests a new, personalized form of brain stimulation (called TMS) using MRI scans to target the right areas for people whose depression hasn't improved with medication. It aims to see if this tailored approach works better than standard TMS.
This study tests a specialized type of magnetic brain stimulation (spectral TMS) to treat severe major depression when standard treatments haven’t worked. You may be eligible if you’ve tried several antidepressants and other add-on treatments but still have symptoms.
Hear when a new MDD trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.