Switching HIV medication to dolutegravir/lamivudine for people on opioid therapy
Part of Mental health clinical trials.
This study looks at switching your current HIV medication to a two-drug combination pill called dolutegravir/lamivudine (DTG/3TC). The goal is to see if this simpler regimen is safe and effective for people who are also on opioid agonist therapy. If you qualify, you may have the option to switch to a potentially easier HIV treatment while continuing your opioid therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You are living with HIV and have been on a stable HIV medication regimen (not including DTG/3TC) with a low viral load (under 200 copies/mL) for at least 3 months.
- Your CD4 count (a measure of immune health) is at least 200 cells/mL.
- You have been on opioid agonist therapy (e.g., methadone or buprenorphine) for at least 3 months and are stable on it.
- You do not have chronic hepatitis B, tuberculosis requiring treatment, or severe liver or kidney problems.
- You are not pregnant, planning pregnancy, or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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