Clin2
NCT06655454Possibly a fitRecruiting

Numbing medicine after root canal for pain relief

Pain AssessmentQuality of Life (QOL)Analgesic Use

Part of Brain & nervous system clinical trials.

This study tests whether a long-acting numbing medication (bupivacaine) given after a root canal can reduce pain better than a standard short-acting numbing medicine. It is for people who need a root canal for a tooth that is causing sharp, constant pain.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
150 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are generally healthy (ASA Class I or II).
  • You are 18 years or older.
  • Your blood pressure is below 160/100.
  • You need emergency or planned root canal therapy for a tooth with severe, ongoing pain (symptomatic irreversible pulpitis).
  • You can understand and complete questionnaires in English.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07400471Recruiting· Early Phase 1
Pain relief before root canal: a medicine combination

This trial tests whether a combination of pain medicines given before a root canal can lower pain afterward. It is for people who have moderate to severe tooth pain and are healthy enough for standard treatment.

Chittagong, Chattogram
NCT06980870Recruiting· Phase 2
Pain medicine before root canal for less discomfort

This study tests whether taking ibuprofen or dexamethasone before a root canal can help reduce pain afterward. It's for people with a painful, inflamed tooth nerve who haven't already taken pain medicine for it.

Rawalpindi
NCT07699315Not yet recruiting· Phase 4
Steroid before numbing for painful lower molar root canals

This trial tests whether giving a steroid medicine (dexamethasone) before numbing a painful lower molar makes the numbing work better during a root canal. It may help reduce pain and improve the success of anesthesia.

NCT07403578Not yet recruiting
Cold therapy to improve numbing for painful tooth root canal

This study tests whether applying cold (cryotherapy) to the gum and tooth before the numbing shot can make the anesthesia work better and reduce pain during a root canal for a severely inflamed tooth. If it works, the dentist's numbing may be more effective and you may feel less discomfort during the procedure.

NCT06671743Recruiting· Phase 3
Medication before root canal to reduce pain

This study tests whether taking a medication before a root canal can reduce pain afterward. It is for people who need a root canal on a lower back tooth that has a painful, inflamed nerve but no infection at the root tip.

Ajman
NCT07036237Enrolling by invitation
Comparing pain relief rinses after root canal

This trial tests whether rinsing the tooth with either tramadol (a pain reliever) or dexamethasone (a steroid) after a root canal reduces pain better. It is for people with a single-rooted tooth that has a very painful, inflamed nerve.

Karachi, Sindh

Hear when a new Pain Assessment trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.