Blood test to find T-DXd candidates for breast cancer
Part of Cancer, Skin clinical trials.
This trial uses a blood test to look for tumor DNA in women with a certain type of advanced breast cancer (HR-positive, HER2-low). If the DNA doesn't disappear after starting standard hormone therapy with a CDK4/6 inhibitor, participants may be switched to a targeted drug called T-DXd (trastuzumab deruxtecan).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- Your breast cancer has spread to other parts of the body (metastatic).
- Your cancer is HR-positive (hormone receptor-positive) and HER2-low or ultra-low.
- You have not received any treatment for metastatic breast cancer yet.
- You are able and willing to have a biopsy of a metastatic tumor.
- You can take oral medication and are in generally good health (ECOG 0 or 1).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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