Study of immunotherapy for colorectal and endometrial cancer
Treatments studied
Part of Cancer, Digestive system, Women’s health & pregnancy clinical trials.
This trial tests two immunotherapy drugs, durvalumab and tremelimumab, in people with colorectal or endometrial cancer that has spread or come back. The goal is to understand why some tumors persist or don't respond to treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have colorectal or endometrial cancer that has spread or come back and cannot be removed by surgery.
- Your tumor has a specific genetic feature (MSI-H/dMMR for one group, or MSS/pMMR for the other).
- You must have at least one tumor that can be biopsied (a small sample taken) and another tumor that can be measured on scans.
- You have not had certain immunotherapy drugs before (like anti-PD-1 or anti-CTLA-4).
- You are willing to use effective birth control if there is a chance of pregnancy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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