Testing a microdose drug in solid tumors before surgery
Part of Cancer, Skin clinical trials.
This study tests a tiny amount of an experimental drug (PBA-0111) injected directly into tumors that will be surgically removed later. The goal is to see how the drug affects the tumor tissue, which may help guide future treatments for solid tumors like head and neck cancer, certain sarcomas, or triple-negative breast cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have one of these cancer types: head and neck squamous cell carcinoma, specific soft tissue sarcomas, or triple-negative breast cancer.
- You have a tumor that can be reached with a small needle and is scheduled to be surgically removed.
- You are physically able to carry out daily activities (ECOG score 0-2).
- You haven't had cancer treatment (like chemotherapy, immunotherapy, or radiation) in the last 3 weeks, and no live vaccines in the last 4 weeks.
- You are not pregnant, breastfeeding, or have uncontrolled infections or autoimmune diseases needing strong medication.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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