Maintenance therapy for stable metastatic pancreatic cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of two drugs, niraparib and ipilimumab, as a maintenance treatment for people with metastatic pancreatic cancer that has not grown after initial chemotherapy. The goal is to see if this can help keep the cancer stable longer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have metastatic pancreatic cancer that has been stable or improved after 4-6 months of a specific type of chemotherapy called FOLFIRINOX or NALIRIFOX.
- You are 18 years or older.
- You are willing to have a tumor biopsy before and during treatment if medically possible.
- You have good organ function and an ECOG performance status of 0 or 1 (meaning you are active or able to carry out light work).
- You have not previously been treated with a PARP inhibitor (like niraparib) or an immunotherapy called ipilimumab.
- You do not have certain genetic changes in BRCA, PALB2, RAD51C, or RAD51D genes, or a mismatch repair deficiency.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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