Psilocybin therapy for irritable bowel syndrome
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether psilocybin-assisted psychotherapy can help people with severe irritable bowel syndrome (IBS) who have not gotten better with standard treatments. Psilocybin is a psychedelic substance that may help reset brain-gut connections to reduce symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe IBS (as defined by a symptom score or needing emergency care for belly pain in the past year).
- IBS symptoms persist despite taking IBS medicines.
- You have a support person who can accompany you home after the psilocybin dose.
- If you can become pregnant, you agree to use effective birth control during the study.
- You are willing to share your outside medical records to confirm eligibility.
- You are not taking certain medications (like antidepressants or other serotonin-related drugs) and have no serious heart, liver, kidney, or mental health conditions that could make the treatment unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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