Ketamine for pain after major orthopedic surgery: drip vs. pump
Treatments studied
Part of Pain clinical trials.
This study tests two ways of giving a medicine called ketamine to control pain after major bone or joint surgery. One method is a steady infusion (drip) through a vein, and the other is a patient-controlled pump (PCA) that lets you press a button for more medicine when you need it.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You are scheduled for a planned (not emergency) major bone or joint surgery
- You are in generally stable health (ASA class 1, 2, or 3)
- You do not have active kidney injury, liver failure, or active heart problems
- You are not pregnant
- You have not had a bad reaction to ketamine or opioid pain medicines before
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
This study tests whether giving ketamine during heart surgery can help prevent long-term pain. It may help patients who are having planned, non-emergency open-heart surgery.
This study tests whether giving ketamine before or during surgery can reduce pain afterward. It is designed for adults with higher body weight who also have certain health conditions like well-controlled diabetes or blood pressure.
This study compares two pain medicines, morphine and ketamine, given through an IV, to see which works better for severe pain from a broken arm or leg bone or belly pain. If you have severe pain and your doctor decides you need morphine, you may be eligible to join.
This study tests a combination of two medications (dexmedetomidine and esketamine) to help manage moderate-to-severe pain after spine surgery. You would receive these drugs through an IV pump that you control to give yourself pain relief as needed.
This study tests if a low dose of ketamine (a pain medicine) given before spinal anesthesia can prevent dangerously low blood pressure during orthopedic surgery. It might help keep your blood pressure steady, making the procedure safer.
Hear when a new Opioid Use trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.