Brain-gut medicine trial for chronic esophagus issues
Part of Digestive system clinical trials.
This trial tests a type of brain-gut medicine to see if it helps with ongoing esophagus problems like heartburn, acid reflux, a lump in the throat, trouble swallowing, or chest pain. It might help if other treatments haven't worked well.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old and able to give consent.
- You have long-term symptoms like heartburn, acid reflux, a feeling of something stuck in your throat, trouble swallowing, or chest pain.
- You do not have a narrowed esophagus or past surgery on your esophagus, stomach, or throat.
- You do not have certain esophagus diseases like erosive esophagitis or eosinophilic esophagitis.
- You have not taken certain medicines for your nerves or stomach in the past month (like strong painkillers or calcium channel blockers).
- You have not taken antidepressants or other psychiatric medicines in the past three months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if a cognitive-behavioral therapy (a type of talk therapy that helps change thoughts and habits) can improve chronic throat and chest symptoms like heartburn, reflux, lump in throat, or trouble swallowing. It is for people who have these symptoms without a known structural problem in the esophagus.
This study tests a comprehensive program that combines diet and lifestyle changes to help people with chronic acid reflux (heartburn, acid regurgitation, or chest pain) feel better. It looks at how these changes can improve your overall health and reduce symptoms.
This trial tests a new medicine called anaprazole for people with moderate to severe reflux esophagitis (chronic heartburn and damage to the food pipe). It compares anaprazole to a standard treatment to see which works better and is safer.
This trial tests whether taking probiotics (healthy bacteria) and zinc supplements together can help reduce symptoms of acid reflux (GERD) and improve the health of your esophagus. It is a phase 4 study, which means these treatments are already in use, and this trial looks at how well they work in real-world patients.
This study tests whether a probiotic called Lactobacillus rhamnosus GG can improve gut bacteria changes caused by proton pump inhibitors (acid-reducing medicines). It mainly involves people who are otherwise healthy and do not currently have ongoing stomach or gut symptoms.
This study tests a new medicine called vonoprazan to see if it can reduce episodes of heartburn in people who have GERD but no damage to their esophagus. It compares the medicine to a placebo (a pill with no active ingredient) over 24 weeks.
Hear when a new Gut-Brain Disorders trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.