Clin2
NCT07752407Possibly a fitRecruiting

Heartburn relief study for people with non-erosive GERD

Symptomatic Non-erosive Gastroesophageal Reflux Disease

Treatments studied

Part of Digestive system clinical trials.

This study tests a new medicine called vonoprazan to see if it can reduce episodes of heartburn in people who have GERD but no damage to their esophagus. It compares the medicine to a placebo (a pill with no active ingredient) over 24 weeks.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
500 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be 18 years or older.
  • You have heartburn as your main symptom, and you've had it for at least 6 months.
  • You have heartburn on 4 or more days each week, on average.
  • You are willing to use birth control if you could become pregnant.
  • You do not have severe damage to your esophagus (like erosive esophagitis or Barrett's esophagus).
  • You are not currently taking certain heartburn medications (like PPIs) and agree not to use them during the study.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06660342Recruiting
Safety of vonoprazan in pregnant women study

This study looks at the safety of vonoprazan (a medicine for acid reflux) when taken during pregnancy. It follows pregnant women who took the drug and those who didn't, to see how it affects mothers and their babies.

Wilmington, North Carolina
NCT06953986Recruiting
Comparing three medicines for severe acid reflux healing

This trial tests vonaprazan (two doses) against esomeprazole to see which better heals moderate-to-severe reflux esophagitis (a damaged esophagus from acid reflux) in 8 weeks. You may qualify if you have had heartburn or regurgitation for at least a month and your doctor found grade B, C, or D damage on an endoscopy.

Hyderabad, Telangana
NCT07437768Enrolling by invitation
Vonoprazan test for acid reflux that doesn't respond to standard medicine

This trial tests a medicine called vonoprazan for people whose acid reflux symptoms (like heartburn or coughing) don't get better with usual treatment. It aims to see if vonoprazan can help control those symptoms.

New Taipei City, Taiwan
NCT06720610Not yet recruiting· Phase 4
Comparing two acid reducers for healing esophagus damage

This trial compares two medicines—vonoprazan and esomeprazole—to see which is better at healing acid damage to the esophagus (erosive esophagitis). If you have had heartburn and an endoscopy confirmed inflammation, you may be eligible for this study.

East Jakarta, DKI Jakarta
NCT07624383Recruiting
New topical treatment for nonerosive acid reflux disease

This study tests a new topical treatment for people with chronic heartburn and acid regurgitation who don't have erosions (damage) in their esophagus. The treatment is applied directly to the affected area and may help relieve symptoms without taking daily pills.

Warsaw, Masovian Voivodeship
NCT06955520Recruiting
Comparing two heartburn drugs after POEM surgery

This study compares two medications—vonoprazan and esomeprazole—to see which one heals acid reflux-related damage in the esophagus better after POEM surgery for achalasia. If you have had POEM and now have heartburn and moderate to severe esophagitis, this trial may help find the best treatment for you.

Hyderabad, Telangana

Hear when a new Symptomatic Non-erosive Gastroesophageal Reflux Disease trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.