Study of a refillable eye implant for wet AMD
Treatments studied
Part of Eyes & vision clinical trials.
This trial tests a refillable eye implant (PDS) that slowly releases medication to treat wet age-related macular degeneration (nAMD). It aims to see if replacing the implant every 36 weeks works as well as regular eye injections.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You were diagnosed with wet AMD within the last 2 years
- You have had at least 3 anti-VEGF injections (like Lucentis or Avastin) for wet AMD in the last 6 months
- Your vision improved after these injections
- You have records of your vision test and retinal scans from before your first injection
- Your current vision in the study eye is 20/200 or better (able to read some letters on an eye chart)
- You have not had certain eye surgeries (e.g., vitrectomy, glaucoma surgery) or treatments (e.g., steroid injections, previous eye implants)
- You do not have other eye diseases that could affect the study results
- You have not had a stroke or heart attack in the last 3 months
- You are not currently using oral steroids or systemic anti-VEGF medications
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial studies whether continuing treatment with a refillable eye implant (Port Delivery System) and ranibizumab injection helps control a specific type of wet macular degeneration. It’s mainly for people who already finished an earlier related study and are able to keep up with frequent eye checks and procedures.
This trial checks how well corneal endothelial cells (cells that help keep the cornea clear) do in people with neovascular age-related macular degeneration (nAMD) who are treated with a port-delivery implant that releases ranibizumab. It also helps doctors understand whether this method changes corneal health and stays safe while controlling the eye disease.
This Phase 3 study tests whether a small eye implant that delivers medicine on a schedule (the port delivery system) with ranibizumab works better and safely in people with wet age-related macular degeneration. It’s designed for patients who have already been treated recently with anti-VEGF injections and need continued control.
This study tests whether a new eye injection called ABP 938 works as well as or better than the current standard treatment (Eylea) for wet age-related macular degeneration—a condition that causes vision loss in the center of your sight. You would receive injections into your eye every month for a year.
This study tests a new medicine called IBI302 for wet age-related macular degeneration (AMD). It aims to slow vision loss by targeting both blood vessel growth and inflammation. You might qualify if you have active wet AMD and have not had certain injections recently.
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