Synbiotics for adults with mild to moderate depression
Part of Mental health clinical trials.
This pilot study tests whether taking a combination of probiotics and prebiotics (synbiotics) can improve mood in adults with depressive symptoms. It may be an option if you have mild to moderate depression and are looking for a supplement-based approach.
Summary written for real people, not researchers, by Clin2.
Who can take part
- 18 years or older
- Have depressive symptoms such as low mood or loss of interest (scoring between 5 and 14 on a standard depression questionnaire)
- Can read and fill out questionnaires
- Understand and agree to take part in the study
- Not currently abusing substances or dependent on them
- No history of bipolar disorder, mania, schizophrenia, personality disorder, PTSD, intellectual disability, Parkinson's disease or other organic brain disorder
- Not at immediate risk of self-harm or attempted suicide in the past 3 months
- Not taking antipsychotics, antidepressants, or sedatives, or on a stable dose for the past 4 weeks
- Free from severe organ failure, dialysis for kidney failure, HIV infection
- No active cancer within the past 5 years
- No major stomach or bowel surgery (except gallbladder or appendix removal) in the past 5 years
- Do not work night shifts
- No antibiotics in the past 4 weeks
- No known severe allergy to probiotics or lactose
- Not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if probiotics can help reduce symptoms of mild to moderate anxiety or depression. It is for people aged 18–60 who are not currently taking most anxiety or depression medications and who have not used them in the last 2 weeks (except for escitalopram).
This study tests whether a probiotic supplement called PB-18 can help reduce symptoms of mild to moderate depression. Probiotics are live beneficial bacteria that may affect mood through gut-brain connection.
This study tests whether a probiotic supplement can help improve depression in young people who are already taking an SSRI antidepressant. If you join, you will take a probiotic or placebo for several weeks and have your mood and brain activity checked.
This trial tests whether taking probiotics can help with mild to moderate depression symptoms. It also looks at how probiotics affect brain activity.
This trial tests a probiotic called IBNI617 for people with moderate to severe depression who are not currently taking antidepressant medication. It aims to see if this probiotic can help improve mood and depression symptoms.
This study tests whether adding psychobiotics (special probiotics for mental health) to your current antidepressant helps treat major depression better than the antidepressant alone. It may be an option if you have moderate to severe depression and are on a stable antidepressant dose.
Hear when a new Depressive Symptoms Mild to Moderate in Severity trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.