Clinical trials
Depressive Symptoms Mild to Moderate in Severity clinical trials
Below are recruiting depressive symptoms mild to moderate in severity clinical trials, each written for real people, not researchers. We’re tracking 24 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06537869Recruiting
Online therapy for older adults with depression in primary care
This trial tests an internet-based cognitive behavioral therapy (iCBT) program for people over 65 with mild to moderate depression. It aims to see if online counseling can help improve mood and can be used in regular doctor visits.
GothenburgAges 65 years+ - NCT06273995Recruiting
Behavioral activation through telehealth for teens with depression
This trial tests if a telehealth program can help teenagers with depression feel better by increasing positive activities. You and a caregiver will attend weekly video sessions for 8 weeks.
Houston, TexasAges 12–18 - NCT06456931Recruiting
Buddhist vs. secular mindfulness for lingering depression
This study compares two types of mindfulness training for people with lingering depression symptoms (not fully recovered). One uses traditional Buddhist meditation, the other uses a common secular approach. It aims to see which helps reduce residual depression better.
Ragama, GampahaAges 18 years+ - NCT06905223Recruiting
Synbiotics for adults with mild to moderate depression
This pilot study tests whether taking a combination of probiotics and prebiotics (synbiotics) can improve mood in adults with depressive symptoms. It may be an option if you have mild to moderate depression and are looking for a supplement-based approach.
Hong KongAges 18 years+ - NCT04123314RecruitingEarly Phase 1
Psilocybin study for depression in mild memory or early Alzheimer’s
This early-phase study tests whether psilocybin (a psychedelic substance) can help with depression in people who have mild memory problems or early Alzheimer’s. The trial also closely monitors safety, thinking changes, mood, and blood pressure before and after dosing.
Baltimore, MarylandAges 18–85 - NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55 - NCT06390462Recruiting
Counseling for teens in school-based primary care
This study tests a brief counseling approach called Interpersonal Counseling for Adolescents (IPC-A) in school settings. It aims to help teens with emotional or social challenges before they become more serious, and it's designed for those who aren't already in mental health treatment.
HämeenlinnaAges 13–16 - NCT07284446Recruiting
Depression, memory, and outcomes in heart failure patients
This study looks at how depression and memory problems affect recovery in people hospitalized with worsening chronic heart failure. It aims to find better ways to support patients during their hospital stay.
KaunasAges 18–85 - NCT06384209Recruiting
Friendship Bench Plus for Depression
This study tests whether a structured talk therapy program called the Friendship Bench can help adults with moderate to severe depression. You will have conversations with trained lay counselors who guide you through problem-solving techniques.
HarareAges 18 years+ - NCT06741540Recruiting
TDCS for breast cancer patients with mild to moderate depression
This trial tests if transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can help improve mood and treatment outcomes in breast cancer patients with mild to moderate depression who are receiving neoadjuvant chemotherapy before surgery.
Hangzhou, ZhejiangAges 18–65 - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT07464886RecruitingPhase 3
NAC and mindfulness therapy for depression in youth
This study tests whether a supplement called N-acetylcysteine (NAC) combined with a type of therapy called Mindfulness-Based Cognitive Therapy (MBCT) can help improve depression in teenagers and young adults. It looks at how these treatments affect brain chemicals and may reduce symptoms.
Cincinnati, OhioAges 15–24 - NCT05892965Recruiting
Instant-message online therapy for early post-stroke depression
This study tests whether brief online cognitive behavioral therapy (CBT) delivered through instant messages can reduce depression symptoms after a stroke. It may help if your depression started after your stroke and you have mild to moderately severe symptoms.
Hong KongAges 18 years+ - NCT07391540Recruiting
Internet therapy for financial stress
This trial tests an internet-based cognitive behavioral therapy (ICBT) program for people feeling mild to moderate psychological symptoms because of money worries. It aims to see if online treatment can help reduce these symptoms.
Linköping, Östergötland CountyAges 18 years+ - NCT06658041Recruiting
A step-by-step program for mild to moderate depression
This trial tests a structured support program for adults with mild to moderate depression. It uses a team-based approach in primary care to help you feel better step by step.
Hong Kong, HONG KONGAges 45–59 - NCT06078007Recruiting
App for depression and anxiety in college students
This trial tests if a guided mobile app can help college students with mild to moderate depression or anxiety. You might benefit if you are not currently receiving mental health treatment and have a smartphone.
Palma de Mallorca, Balearic IslandsAges 18 years+ - NCT06085313Recruiting
Web-based program for cancer pain in Asian women
This trial tests a web-based program to help women of Chinese, Korean, or Japanese heritage manage breast cancer pain and depressive symptoms. If you've had breast cancer, have had pain in the past week, and feel some depression, this program could help you cope better.
Austin, TexasAges 18 years+ - NCT07631845Recruiting
Music and breathing exercises to improve mood and resilience in older adults
This study tests whether combining music with breathing exercises can help older adults manage anxiety and depression. You'll learn techniques that may improve your emotional well-being and resilience.
Hong KongAges 65 years+ - NCT07208162Recruiting
SHARE program for African American families facing memory loss
This study tests a program called SHARE, which helps African American families work together when a loved one has early-stage memory loss. It focuses on improving communication and support at home.
Cleveland, OhioAges 18 years+ - NCT07630545RecruitingPhase 1
Testing a new drug for Parkinson's disease
This study tests an experimental drug, MTX325, in people with Parkinson's disease. The goal is to see if it is safe and how the body processes it, which may lead to new treatment options.
AdelaideAges 18–75 - NCT07142291RecruitingPhase 2
Cromolyn inhaler for early ALS
This trial tests if an inhaled drug called cromolyn can help people with early-stage ALS. It is for people who can still breathe well and are not yet using a ventilator.
Scottsdale, ArizonaAges 18–75 - NCT06531980Recruiting
Digital app for teens with mild to moderate anxiety
This trial tests a digital app to help teens with mild to moderate anxiety. If you are 13–16, live in Bergen, and feel anxious often, this app might help you manage your worries and get back to doing things you enjoy.
Bergen, VestlandAges 13–16 - NCT04500847RecruitingPhase 1
Testing repurposed HIV-like drugs for early Alzheimer’s symptoms
This Phase 1 study tests whether an existing type of anti-viral medicine (nucleoside reverse transcriptase inhibitors) can help people with early Alzheimer’s disease. It also focuses on safety and proper dosing while measuring brain-related changes and memory-related symptoms.
Los Angeles, CaliforniaAges 50–85 - NCT07499570Recruiting
Talk therapy using AI for older adults with memory issues
This study tests an AI-powered talk therapy for older adults with mild memory problems who live at home. It aims to reduce challenging behaviors like agitation, anxiety, or depression by delivering personalized support through a computer or tablet.
Indianapolis, IndianaAges 65 years+
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Common questions
- Are there clinical trials for depressive symptoms mild to moderate in severity?
- Yes. Clin2 currently lists 24 recruiting depressive symptoms mild to moderate in severity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive symptoms mild to moderate in severity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive symptoms mild to moderate in severity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.