Probiotics to treat anal precancer (PROTECT trial)
Part of Cancer, Digestive system, Infections clinical trials.
This study tests if a probiotic called EXE-346 can help clear anal high-grade squamous intraepithelial lesions (HSIL), a precancerous condition, in people with HIV who are on effective antiretroviral therapy. If you have anal HSIL that wasn't fully removed by biopsy, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have anal HSIL (a precancerous spot) that was not completely removed by biopsy.
- You are on HIV treatment (antiretroviral therapy) for at least 3 months, with a viral load under 200.
- Your CD4 count (a measure of immune health) has never been below 200.
- You are generally in good health (able to do daily activities) and have normal blood counts.
- You are not pregnant or breastfeeding, and if you could become pregnant, you agree to use effective birth control.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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