Optimizing first treatment and studying gut bacteria in pancreatic cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests whether a combination of chemotherapy drugs (NALIRIFOX) is effective as a first treatment for pancreatic cancer that has spread. It also studies how gut bacteria affect the success of a second treatment with gemcitabine and paclitaxel. The goal is to find better ways to treat pancreatic cancer by personalizing therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your cancer must be a type called pancreatic ductal adenocarcinoma (PDAC) that has been confirmed by a biopsy.
- You must have at least one tumor that can be measured on a CT scan or MRI.
- You must be 18 years or older; if over 75, you need a special health assessment (G8 score).
- You must be able to perform daily activities without significant help (ECOG performance status 0 or 1).
- You must have adequate organ function, such as enough red blood cells, white blood cells, and kidney and liver function.
- You must not have had prior chemotherapy for advanced pancreatic cancer, unless it's for a second-line treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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