Ivonescimab with chemotherapy for advanced stomach or esophageal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) for people with advanced adenocarcinoma of the esophagus, stomach, or gastroesophageal junction. The drug is designed to help the immune system fight cancer. The study is for people who have not had prior treatment for stage IV disease and whose cancer is HER2 negative.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have adenocarcinoma of the esophagus, stomach, or gastroesophageal junction (not squamous cell).
- Your cancer must be HER2 negative.
- You must not have had prior treatment for stage IV cancer.
- Your disease must be measurable or evaluable by imaging or physical exam.
- You must have adequate bone marrow, liver, and kidney function.
- You must not have active brain metastases or leptomeningeal disease.
- You must not have had major surgery within 4 weeks before registration.
- You must not have had prior treatment with a PD-1 or PD-L1 inhibitor.
- You must not have uncontrolled high blood pressure.
- You must not have a history of bleeding problems or blood clots within the last 4 weeks.
- You must not have had non-infectious pneumonitis requiring treatment within 4 weeks.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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