Clin2
NCT07100184Possibly a fitNot yet recruiting

Targeted medicine with radiation for bladder cancer

HER2-expressing High-risk or Very High-risk NMIBC Without Visible Foci of Disease After TURBT

Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.

This study tests a new targeted medicine combined with radiation for bladder cancer that has not spread into the muscle. It is for people with a specific protein on their tumor (HER2) who cannot get or benefit from standard BCG treatment.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
30 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older and willing to join the study.
  • You have had bladder cancer that has not gone into the muscle layer and you have had surgery to remove it within the past 4 weeks.
  • Your tumor shows a certain protein called HER2 (score of 2+ or 3+).
  • You are unable or unwilling to get BCG treatment, or BCG did not work for you.
  • Your cancer is considered high or very high risk of returning.
  • Your overall health is good enough to participate (no severe heart, liver, or kidney problems).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07142200Not yet recruiting· Phase 2
Combination treatment to save the bladder in HER2-positive muscle-invasive bladder cancer

This study tests a combination of a targeted drug (disitamab vedotin), an immunotherapy drug (PD-1 inhibitor), and radiation therapy as a way to treat bladder cancer without removing the bladder. It is for people whose cancer has grown into the bladder muscle but hasn't spread to other parts of the body, and whose tumor shows high HER2 levels.

Shanghai, Shanghai Municipality
NCT07783815Not yet recruiting· Phase 1
Bladder cancer treatment combining two newer drugs

This trial tests a new combination of two medications—one that targets HER2 on cancer cells and one that boosts your immune system—given directly into the bladder. It is for people with high-risk bladder cancer that hasn't spread into the muscle, and who haven't had BCG therapy or for whom BCG didn't work.

Changsha, Hunan
NCT06630871Not yet recruiting· Phase 2
Targeted therapy before repeat bladder surgery for high-risk bladder cancer

This trial tests a combination of two drugs (disitamab vedotin and tislelizumab) given before a second bladder surgery (re-TURBT) for people with high-risk non-muscle invasive bladder cancer that has high HER2 levels. The goal is to see if this approach improves outcomes compared to standard care.

Fuzhou, Fujian
NCT07646145Recruiting· Phase 2
Disitamab Vedotin Plus Mitomycin C for HER2-Positive Bladder Cancer

This trial tests a combination of two medications—disitamab vedotin (a targeted therapy) and mitomycin C (a chemotherapy)—for people with early-stage bladder cancer that has a specific protein called HER2. The goal is to prevent cancer from coming back after surgery in people who cannot or will not receive BCG treatment.

Taiyuan, Shanxi
NCT06378242Recruiting· Phase 1/Phase 2
Testing a bladder cancer drug for high-risk NMIBC patients

This trial tests a drug called Disitamab Vedotin, given directly into the bladder, for a type of early bladder cancer (high-risk NMIBC) that has a protein called HER2. It aims to see if this treatment can help avoid more radical surgery.

Guangzhou, Guangdong
NCT07207824Recruiting· Phase 3
Study of a new drug for high-risk bladder cancer

This trial tests a combination of a drug (DV) and BCG immunotherapy for people with high-risk, early-stage bladder cancer that has not spread into the muscle. The cancer must show a specific protein called HER2 on its cells.

Shanghai, Shanghai Municipality

Hear when a new HER2-expressing High-risk or Very High-risk NMIBC Without Visible Foci of Disease After TURBT trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.