Early eptinezumab infusions for post-traumatic headaches
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests whether giving eptinezumab (an antibody that blocks a pain protein) soon after a head injury can reduce the severity and duration of headaches that start after trauma. If you've had new or worsening headaches within the past 8 weeks after a head injury, this treatment might help prevent them from becoming chronic.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have headaches that started or worsened within 8 weeks after a head injury
- Your headaches must meet the official criteria for post-traumatic headache
- You must not have had a moderate or severe traumatic brain injury (TBI) or a mild TBI in the last 5 years
- You must not have other headache disorders (like migraine or tension-type) before the injury
- You must not be using certain migraine drugs (CGRP inhibitors or Botox) in the last 3 months
- You must not have opioid or substance use disorder, or be on opioids for headaches more than 4 days a month
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
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