High-dose antibiotics plus methenamine for chronic UTI in women
Part of Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial compares a new treatment approach—high-dose antibiotics combined with methenamine hippurate—against standard care for women with chronic urinary tract infections (UTIs). It aims to find if the combination works better at relieving persistent symptoms like pain and frequent urination.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have had daily symptoms of a urinary tract infection (such as needing to pee often, sudden urges to pee, bladder or urethra pain) for at least 3 months.
- Your symptoms have improved before with antibiotics for a UTI.
- You are a woman (assigned female at birth) and are 18 years or older.
- Your kidney function must be at a certain level (eGFR of 45 or higher on a blood test).
- You cannot have certain medical conditions like bladder cancer, active sexually transmitted infection, or be currently taking certain medications (e.g., immune-suppressing drugs or SGLT2 inhibitors).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether taking the supplement vitamin C together with the medication Hiprex (methenamine hippurate) can help prevent repeated urinary tract infections (UTIs) in women. If you have frequent UTIs, this combination might offer a new way to reduce how often they happen.
This study compares a non-antibiotic medicine (methenamine) to antibiotics for preventing urinary tract infections after a common incontinence surgery (mid-urethral sling). It may help people avoid antibiotics and their side effects.
This study tests a personalized approach to treat and prevent recurring urinary tract infections (UTIs) in women aged 65 and older. It aims to find the best way to manage symptoms and reduce future infections.
This Phase 2 trial tests LBP-EC01 to treat a bladder infection (UTI) caused by drug-resistant E. coli. It may help by targeting the specific bacteria that make UTIs harder to cure with common antibiotics.
This trial tests an investigational tablet called Fluorothiazinone for women with chronic bladder infections (cystitis) that keep coming back. It aims to see if the drug is safe and helps relieve symptoms like pain and frequent urination.
This trial tests a therapy (called GAG therapy) to prevent repeat urinary tract infections (UTIs) in adult women. It compares how similar the results are to a well-known antibiotic standard (nitrofurantoin) to see if it works reliably.
Hear when a new Chronic Urinary Tract Infection trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.