Study of DONQ52 for active celiac disease
Part of Digestive system, Hormones & metabolism clinical trials.
This trial tests a new drug called DONQ52 in people with active celiac disease who still have symptoms despite following a gluten-free diet. The goal is to see if DONQ52 can help reduce damage to the small intestine and improve gluten-related symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with celiac disease by a doctor and your medical records show it.
- You have followed a gluten-free diet for at least 12 months.
- You have had at least 2 gluten-related symptom episodes (like diarrhea, stomach pain, bloating, nausea, or tiredness) in the past month.
- You have a specific genetic type (HLA DQ2.5) that is common in celiac disease.
- You are willing to eat a gluten-free product and a special gluten challenge product, and have 2 upper endoscopies with biopsies.
- You have ongoing small intestine damage (villous height to crypt depth ratio of 2.5 or less).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests an experimental medication for adults with celiac disease to see if it can protect against gluten exposure. You will need to follow a gluten-free diet and undergo a short, planned gluten challenge.
This trial tests a new medicine, ZED1227, for people with celiac disease who still have symptoms despite eating gluten-free. The goal is to see if it helps reduce those symptoms.
This study tests a new medicine called HB-2121 used as a diagnostic tool during an upper endoscopy to help improve detection of celiac disease. It's designed for people who are already scheduled for this procedure and may help doctors see the gut damage caused by celiac more clearly.
This study helps people newly diagnosed with celiac disease learn to use a gluten-detection device and get education to better manage their diet and health.
This study looks at how the gut lining “tissues” are affected during gluten eating versus avoiding gluten in people with celiac disease. It may help researchers understand what drives healing and tissue damage in celiac disease.
This trial compares different forms of gluten to see which one causes the strongest immune reaction in people with celiac disease. It may help doctors choose the best way to test gluten sensitivity in the future.
Hear when a new Celiac Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.