CAR T-cell therapy for relapsed or refractory DLBCL
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new CAR T-cell therapy called MB-CART2019.1 for people with diffuse large B-cell lymphoma (DLBCL) that has come back or not responded after at least two prior treatments. The therapy uses your own immune cells to fight the cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a type of DLBCL confirmed by biopsy, including common subtypes or lymphoma that has transformed from a less aggressive form.
- Your lymphoma has returned or not responded after at least two prior chemotherapy regimens that included rituximab and an anthracycline drug.
- You are either not eligible for a stem cell transplant, chose not to have one, or had one that didn't work or your cancer came back within 2 years.
- You are 18 years or older and have a good performance status (able to carry out daily activities), even if you feel somewhat limited due to the lymphoma.
- You have measurable disease on a PET/CT scan, and if needed, you have archived tumor tissue available or are willing to have a new biopsy.
- You do not have active lymphoma in the brain or spinal cord, and your heart, kidneys, liver, and blood counts meet specific health criteria.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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