Precision Medicine in Achalasia (PREMEDIA) Study
Part of Digestive system clinical trials.
This study at Northwestern University is looking for people with certain severe esophageal motility disorders (like achalasia) to see if a personalized medicine approach can improve treatment. It focuses on those who haven't had prior surgery or recent endoscopic treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older.
- You must have a specific type of esophageal motility disorder: type III achalasia, spastic EGJOO, Jackhammer esophagus, or distal esophageal spasm.
- Your Eckardt score (measuring swallowing difficulty, chest pain, and weight loss) must be greater than 3.
- You cannot have had prior POEM or other surgical treatment for achalasia.
- No endoscopic dilation or Botox injection for achalasia in the last 6 months.
- No prior stomach or esophageal surgeries, including weight-loss or GERD procedures, or other conditions like cancer-related swallowing problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares different treatments for achalasia or related swallowing problems. It aims to find the best personalized approach to improve your symptoms.
This study compares different versions of a procedure called POEM for treating achalasia, a condition where the food pipe has trouble moving food into the stomach. You may be considered if you have specific achalasia types and symptoms that are still significant despite treatment.
This study tests detailed ways to measure esophagus movement and symptoms in people with achalasia or other esophagus motility disorders. It may help doctors better diagnose these conditions and improve how treatment planning and outcomes are tracked.
This study tests a procedure called POEM-F for achalasia types I–II or III. It may help people who haven't had treatment or who've had balloon dilation before.
This trial looks at people who had a procedure called POEM for achalasia and want to understand outcomes after that treatment. If you’re an adult and already had POEM for achalasia, you may be able to join.
This trial compares two ways of doing a procedure called POEM for people with type II achalasia, a condition where the muscle at the bottom of the esophagus doesn't relax properly. It tests whether a shorter or longer tunnel under the lining of the esophagus works better to help you swallow comfortably.
Hear when a new Type III Achalasia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.