One vs three HIPEC treatments after surgery for appendix cancer
Part of Cancer clinical trials.
This trial compares two different schedules of heated chemotherapy (HIPEC) after surgery for pseudomyxoma peritonei (a rare appendix cancer that spreads in the abdomen). It may help determine whether one or three cycles of HIPEC is better for controlling the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have pseudomyxoma peritonei (a type of appendix cancer) that is low-grade, high-grade, or high-grade with signet-ring cells.
- You have already had or are planning to have surgery to remove visible tumors (CRS) plus heated chemotherapy (HIPEC).
- Your cancer covers a large area in the abdomen (PCI score of 15 or higher on a scan).
- You are generally healthy enough for major surgery (KPS score above 60) and your major organs (blood counts, liver, kidneys, heart, lungs) work well.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares a lower dose of heated chemotherapy (HIPEC) given during surgery to a standard dose for patients with pseudomyxoma peritonei (a condition where jelly-like mucus builds up in the abdomen). The goal is to see if the lower dose works just as well with fewer side effects.
This trial tests a chemotherapy combination (capecitabine and cyclophosphamide) given before surgery for people with a large amount of pseudomyxoma peritonei (PMP). The goal is to see if it can shrink the tumor and make surgery more effective.
This study looks at how cancers that spread along the belly lining (“peritoneal surface malignancies”) behave and how different treatment strategies may work. It may help improve how doctors select and test treatments for people who are candidates for CRS-HIPEC, a specific cancer surgery approach.
This study tests a personalized way to deliver heated chemotherapy directly into the belly during surgery for advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if tailoring the chemo drugs to your tumor can improve outcomes.
This Phase 2 study tests whether a modified chemotherapy given inside the abdomen soon after surgery is practical and safe. It may help people with appendix or colon cancer that has spread within the abdomen (peritoneal carcinomatosis) by targeting cancer cells after tumor removal.
This study looks at adding a heated medicine treatment (HIPEC with mitomycin C) during surgery to treat colon cancer that has spread to the lining of the abdomen (peritoneum). It aims to improve outcomes after surgeons remove visible tumor completely.
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