Feasibility of modified chemotherapy after bowel surgery
Part of Cancer, Digestive system clinical trials.
This Phase 2 study tests whether a modified chemotherapy given inside the abdomen soon after surgery is practical and safe. It may help people with appendix or colon cancer that has spread within the abdomen (peritoneal carcinomatosis) by targeting cancer cells after tumor removal.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years or older
- Have appendix or colon cancer that has spread in the lining of the abdomen
- Have completed staging tests (CT scan, and PET scan if your doctor thinks it’s needed, plus laparoscopy/assessment if required)
- Be recommended by a cancer team for surgery called CRS + HIPEC, followed by this modified early chemotherapy (mEPIC)
- Be able to have surgery within 4–6 weeks of finishing any pre-surgery treatment (or within 4–6 weeks of joining if you don’t have pre-treatment)
- Have blood and organ tests in safe ranges (neutrophils and platelets high enough, kidneys and liver work well enough)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests whether spraying chemotherapy into the abdomen (through a small procedure) after colon cancer surgery can lower the chance the cancer comes back. It is meant for people with high-risk tumor features but who have had surgery and have no proven relapse yet.
This study looks at adding a heated medicine treatment (HIPEC with mitomycin C) during surgery to treat colon cancer that has spread to the lining of the abdomen (peritoneum). It aims to improve outcomes after surgeons remove visible tumor completely.
This study tries to better predict how well patients do after heated chemotherapy placed in the abdomen during surgery for stomach or colon cancer that has spread to the lining of the abdomen. It may help doctors choose the best treatment plan and timing for future patients.
This Phase 1 trial tests a treatment that delivers heated chemotherapy directly into the abdomen (HIPEC) for certain cancers that have spread only within the abdominal lining. It aims to see how safely and effectively this approach works, especially when doctors can remove as much tumor as possible.
This study tests a personalized way to deliver heated chemotherapy directly into the belly during surgery for advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if tailoring the chemo drugs to your tumor can improve outcomes.
This trial compares two different schedules of heated chemotherapy (HIPEC) after surgery for pseudomyxoma peritonei (a rare appendix cancer that spreads in the abdomen). It may help determine whether one or three cycles of HIPEC is better for controlling the disease.
Hear when a new Peritoneal Carcinomatosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.