Blood test to guide cancer monitoring in Lynch syndrome
Part of Cancer, Digestive system, Genetic & congenital, Hormones & metabolism clinical trials.
This study is testing whether a simple blood test can safely replace some of the more invasive procedures used to monitor people with Lynch syndrome, a condition that increases the risk of certain cancers (especially colorectal and uterine). If the blood test works as well, it could mean fewer colonoscopies and other invasive tests for those with Lynch syndrome.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 35 and 80 years old.
- A genetic test must have confirmed a change (called a variant) in one of the Lynch syndrome genes (MLH1, MSH2, MSH6, or EPCAM) that is known to increase cancer risk.
- You must have health insurance or be part of a national health system that covers the cost of your regular medical care and Lynch syndrome screening.
- You cannot have had surgery to remove your entire colon and rectum.
- You cannot have had any cancer treatment (surgery, chemotherapy, or radiation) within the past 2 years, or checkpoint inhibitor therapy (a type of immunotherapy) within the past 12 months.
- You cannot be pregnant.
- You must be willing and able to attend the follow-up visits required by the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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