Drug-coated balloon vs. stent for high-risk heart disease
Part of Heart & circulation clinical trials.
This trial compares two treatments for people with complex coronary artery disease who have high-risk conditions or complicated blockages: a drug-coated balloon (DCB) versus a drug-eluting stent (DES). Both are ways to open up narrowed arteries and keep them open without surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have angina (chest pain) or signs of reduced blood flow to the heart, or had a recent heart attack (more than 48 hours ago) that is stable.
- You have either high-risk conditions (like diabetes, age over 75, kidney disease, recent heart attack, or high bleeding risk) OR your blockages are in multiple arteries, a branch point, very long, or need special calcium treatment.
- Each blockage must be at least 2 mm wide and suitable for either a drug-coated balloon or a drug-eluting stent.
- You are not pregnant, not allergic to required medications (like aspirin, clopidogrel, heparin, contrast dye), and can commit to follow-up visits.
- You have not had a stent placed in the same vessel before, or if you did, it was over 30 days ago (except for a recent heart attack) and the blockage is not in a bypass graft or completely closed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a drug-coated balloon, used without a permanent stent, can safely open completely blocked heart arteries that have been blocked for at least 3 months. It may offer an option that avoids leaving a metal stent behind.
This study tracks outcomes for people having a heart procedure with a drug-coated balloon, which releases medicine to help keep arteries open. It may help doctors learn if this treatment works well for a wider range of patients.
This study looks at how to treat blocked heart arteries that have narrowed again after a prior drug-eluting stent. It compares using another drug-eluting stent versus a drug-coated balloon, chosen based on an imaging scan inside the artery (OCT), to reduce repeat narrowing.
This study compares two treatments for new blockages in large heart arteries: a drug-coated balloon (a balloon that releases medicine) versus a drug-coated stent (a small mesh tube). The goal is to see which one better helps the artery stay open and function normally.
This study looks at how well a drug-coated balloon (a balloon with medicine that opens blocked heart arteries) works, either alone or with a stent, to treat coronary artery disease. It aims to see if this approach is safe and effective over time.
This trial is studying how well drug-coated balloons work for people with coronary artery disease. It looks at their use in many different situations, including new blockages, re-narrowed stents, and complex cases. The goal is to see if they are a good option for opening blocked arteries.
Hear when a new Coronary Artery Disease (CAD) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.