Preventing pain after mastectomy with added medication
Treatments studied
Part of Mental health clinical trials.
This trial tests if adding amantadine or duloxetine to the standard drug pregabalin can better prevent chronic pain after a mastectomy. It may help you if you're undergoing a modified radical mastectomy for breast cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- Your health status is classified as ASA II or III (meaning you have mild to moderate health issues).
- Your body mass index (BMI) is between 20 and 40.
- You are scheduled for a modified radical mastectomy for breast cancer.
- You have not taken antidepressants, anticonvulsants, or opioids before surgery.
- You do not have a history of psychological disorders, chronic pain, or drug abuse.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study compares two methods to prevent long-term pain after breast cancer surgery: a nerve block using ultrasound guidance or an epidural. The goal is to see which helps women feel less pain months after their mastectomy.
This study tests whether a pain-control approach without opioids (strong pain medicines) can lower persistent pain after mastectomy. It may help people avoid long-term pain and opioid side effects.
This study looks at why some people have more pain than others after breast surgery. It aims to find biological and personal factors that affect pain, which could lead to better pain treatments in the future.
This trial tests two different numbing injections to see which one works better for pain after breast cancer surgery. If you are having a mastectomy, you may be able to join and help find a better way to manage pain.
This trial tests whether a specific pain-numbing nerve block given during mastectomy can reduce chronic (long-lasting) pain after breast cancer surgery. It may help some people use less pain medicine later by lowering nerve-related pain after surgery.
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