Dexamethasone and liver enzyme function in healthy men
Treatments studied
This trial tests how the drug dexamethasone affects certain liver enzymes (CYP enzymes) in healthy men. These enzymes help break down many medications, so the results may help doctors understand how to adjust medication doses when patients take dexamethasone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a healthy man between the ages of 19 and 50.
- Your weight must be between 110 lb and 198 lb, and your body mass index (BMI) must be between 18.5 and 29.9.
- You must have a specific CYP2C19 gene type (either normal or poor metabolizer) determined by a genetic test.
- You cannot have any significant medical conditions, including heart, liver, kidney, or stomach issues.
- You must not smoke, and you must be willing to avoid alcohol, caffeine, and grapefruit for a period before the study.
- You must agree to use effective contraception and not donate sperm during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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