Immunotherapy and chemoradiation before liver transplant for bile duct cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of immunotherapy (PD-L1 antibody) with chemotherapy and radiation before a liver transplant for patients with advanced hilar bile duct cancer. It aims to shrink the tumor and improve transplant outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have a confirmed diagnosis of perihilar cholangiocarcinoma (bile duct cancer at the liver hilum) that has not spread to lymph nodes or distant organs.
- Your tumor involves the bile ducts, blood vessels, or liver in a way that makes it locally advanced and not removable by surgery.
- You have not had any prior chemotherapy, radiation, or surgery for this cancer.
- Your overall health is good (able to care for yourself, ECOG 0-1), and your blood counts, liver, and kidney function meet the study's minimum levels.
- You are willing to use effective contraception during the study and for 120 days after the last dose, if applicable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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