VSV Virus Plus Immunotherapy for Advanced Kidney Cancer
Treatments studied
Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests a combination of a special virus (VSV-IFNβ-NIS) with two immunotherapy drugs (ipilimumab and nivolumab) for people with advanced clear cell kidney cancer that hasn't been treated yet. It aims to see if this approach helps shrink tumors or slow the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your kidney cancer has spread beyond the kidney or cannot be removed with surgery, and it has a 'clear cell' component.
- You have not had any prior treatment for advanced or metastatic kidney cancer.
- Your liver and kidney function, along with blood cell counts, are within certain ranges (these are checked by your doctor).
- You are not pregnant or nursing, and if you can have children, you agree to use effective birth control.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of two drugs, RP2 (an oncolytic virus injected into tumors) and tivozanib (a daily pill), for people with advanced kidney cancer that has clear-cell or sarcomatoid features and has grown after prior immunotherapy and a targeted therapy. The goal is to see if this combination can shrink tumors or slow the cancer's growth.
This trial tests whether adding a probiotic (CBM588) to a standard immunotherapy combination (nivolumab and ipilimumab) helps treat advanced kidney cancer. It is for people with a specific type of kidney cancer that has spread or cannot be removed with surgery, who have not had systemic treatment before.
This trial tests a new virus-based treatment (SVV-001) combined with two immunotherapy drugs (nivolumab and ipilimumab) for people with advanced neuroendocrine cancers that have gotten worse after at least one prior treatment. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
This trial tests an experimental virus therapy called VSV-02 for people with advanced solid tumors that have not responded to standard treatments. The treatment is given directly into a tumor, aiming to attack cancer from the inside.
This trial compares two immunotherapy combinations—nivolumab/relatlimab/ipilimumab vs. nivolumab/ipilimumab—as first treatment for advanced kidney cancer with clear cell features. It aims to see which combo works better for people who haven't had prior therapy.
This trial tests a combination of a kidney-cancer vaccine and an immune cell treatment to help stop or shrink renal cell carcinoma. It is designed for people who have measurable tumors and are well enough to participate.
Hear when a new Advanced Clear Cell Renal Cell Carcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.