Brain Wave Changes During Fenfluramine Treatment in Lennox-Gastaut Syndrome
Part of Brain & nervous system, Genetic & congenital clinical trials.
This study tracks how brain wave patterns change when children and young adults with Lennox-Gastaut Syndrome (a severe seizure disorder) take fenfluramine, a medication that helps reduce drop seizures. Researchers will use EEG (brain wave recordings) to understand how this treatment affects the brain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 2 to 35 years old
- Confirmed diagnosis of Lennox-Gastaut Syndrome with seizure onset by age 11
- Currently taking fenfluramine at the correct dose for at least a few weeks
- At least 2 drop seizures per week (recorded recently)
- Taking 1–4 other seizure medications on a stable dose for at least 30 days
- Brain wave (EEG) recording from within 6 months before starting fenfluramine
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if using a small, at-home EEG patch can help doctors adjust the dose of fenfluramine more safely and effectively for people with Dravet syndrome or Lennox-Gastaut syndrome. You may be eligible if you are starting fenfluramine for the first time.
This study tests a new brain stimulation device that adjusts treatment based on your sleep patterns to reduce seizures in Lennox-Gastaut syndrome. The device may help people whose seizures haven't been controlled by medications alone.
This trial tests a new type of brain stimulation (adaptive deep brain stimulation) that adjusts in real time to stop seizures in children with Lennox-Gastaut syndrome. It's for children who haven't gotten enough help from medications and have frequent drop seizures.
This study looks at switching children with Dravet or Lennox Gastaut syndrome from artisanal CBD products to a standardized FDA-approved CBD medication called Epidiolex, to see if it works as well or better for seizure control.
This trial tests the safety of a medicine called fenfluramine for children under 2 years old with Dravet syndrome. It aims to see if fenfluramine can help control seizures in very young children.
This Phase 2 trial studies fenfluramine to treat infantile spasms that haven’t improved after standard medicines (ACTH and vigabatrin). If you/your child has ongoing seizures, the study may offer another treatment option and will monitor safety closely, especially heart-related side effects.
Hear when a new Lennox Gastaut Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.