Minimally invasive reflux surgery for Asian patients with severe heartburn
Part of Digestive system clinical trials.
This trial tests a newer, less invasive surgical procedure called TIF (Transoral Incisional Fundoplication) for patients with severe acid reflux and regurgitation that hasn't improved with high-dose medications. The procedure is done through the mouth rather than the abdomen, and researchers will follow patients for 5 years to see if it works and is safe in Asian populations.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–80 years
- Severe heartburn and regurgitation for at least 6 months, even on high-dose acid-blocking medications (at least 40 mg daily)
- Confirmed excessive stomach acid exposure in the esophagus when off medications for 7 days (measured by a special probe)
- BMI (body weight relative to height) of 35 or less
- No serious uncontrolled medical conditions, Barrett's esophagus longer than 2 cm, hiatal hernia larger than 2 cm, or severe inflammation of the esophagus
- Not pregnant and no plans to become pregnant in the next year
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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