Clin2
NCT07583745Likely a fitNot yet recruiting

EPN-701 Treatment for Calciphylaxis, a Rare Vascular Disease

Calciphylaxis

Part of Hormones & metabolism clinical trials.

This study tests a new drug called EPN-701 for calciphylaxis, a serious condition where calcium deposits damage blood vessels and skin, causing painful sores. If you have this condition and are on regular dialysis, this trial may help reduce your pain and heal your wounds.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
60 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have been diagnosed with calciphylaxis with at least one open sore and moderate to severe pain (5 or higher on a 0–10 pain scale)
  • You need dialysis three times per week due to kidney disease
  • You are at least 18 years old
  • You are not currently hospitalized (or were discharged more than 24 hours before screening)
  • You are not in septic shock and not receiving hospice or comfort care
  • You have not participated in another drug trial in the past 4 weeks

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT03032835Recruiting
Research study for calciphylaxis skin lesions

This study collects and stores information from people with calciphylaxis, a serious condition that causes painful skin lesions. It may help researchers learn more about the disease and improve future care.

Boston, Massachusetts
NCT07708038Not yet recruiting· Phase 1
Testing tocilizumab for calciphylaxis skin disease

This trial tests a drug called tocilizumab (an IL-6 blocker) for people with calciphylaxis, a painful skin condition linked to kidney disease. The goal is to see if the drug can reduce inflammation and improve skin sores.

Boston, Massachusetts
NCT05018221Recruiting· Phase 3
Testing better treatment information for calciphylaxis ulcers

This Phase 3 study is for adults on regular dialysis who have a new calciphylaxis ulcer. It tests a better way to give and use treatment guidance so ulcers may improve with clearer, more consistent care.

Concord, New South Wales
NCT07511283Recruiting
Calciphylaxis study in kidney disease patients

This study looks at a rare condition called calciphylaxis (hardening of small blood vessels) that can happen in people with chronic kidney disease. It aims to learn more about what causes it and how to help those affected.

Odense
NCT04592640Recruiting· Early Phase 1
Amniotic stem cell treatment for calciphylaxis

This early-phase study tests a stem cell therapy made from amniotic (placenta) tissue for people with calciphylaxis. If you qualify, the goal is to see whether this treatment is safe and potentially helpful for this rare, painful condition.

Nanjing, Jiangsu
NCT04654000Recruiting
Rheopheresis to treat painful skin damage in calciphylaxis

This trial studies whether a treatment called rheopheresis, added to standard care, can help people with calciphylaxis whose skin wounds are getting worse. It may be considered when ulcers or dead (necrotic) skin appear despite conventional treatment.

Angers

Hear when a new Calciphylaxis trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.