New drug velzatinib versus imatinib for untreated GIST
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial compares a newer cancer drug (velzatinib) with a standard treatment (imatinib) for gastrointestinal stromal tumors (GIST) that cannot be surgically removed or have spread. You would receive one of these two drugs to see which works better and is safer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18 or older
- Confirmed GIST diagnosis that is either metastatic (spread to other parts of body) or cannot be surgically removed
- No prior chemotherapy or targeted therapy for your GIST
- Tumor tissue sample available (archived or fresh biopsy) for testing
- At least one measurable tumor lesion on imaging
- Good overall health and able to follow study procedures and contraception requirements
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares a new oral drug, IDRX-42, with the standard drug sunitinib (Sutent) for people with advanced GIST whose cancer has progressed after imatinib therapy. The goal is to see if IDRX-42 can better control the tumor growth.
This trial gives patients with advanced GIST access to the investigational drug bezuclastinib combined with sunitinib. It is for people who have already tried imatinib and need another option.
This study tests a new pill called velzatinib for people with GIST that has spread or can't be removed by surgery, after other treatments have stopped working. It may help shrink the tumor or slow its growth.
This study lets people with GIST who are already benefiting from velzatinib in another trial continue taking it. The goal is to keep providing the drug while researchers gather more information on its long-term effects.
This trial tests a new drug, ziftomenib, combined with imatinib for people with advanced or spreading gastrointestinal stromal tumors (GIST) that have a KIT mutation. It may help if your GIST has gotten worse while on imatinib.
This Phase 2 trial tests whether adding atezolizumab (an immune medicine) to imatinib works better than imatinib by itself in people with advanced gastrointestinal stromal tumors (GIST) that can’t be fully removed and have progressed after standard treatments. It may help by improving how well tumors respond and how long disease stays under control.
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